Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Blog Article

Despite growing interest in the role of autophagy in neurons, it remains unclear how this process is regulated, in particular, how autophagy is spatially restricted Speaker Cable in subcellular compartments in neurons.In this study, the MAG MALATE RENEW authors use an unbiased proteomic approach to show that the autophagy initiating kinase UNC-51/ULK and autophagosome formation are inhibited by the ubiquitin ligase RPM-1, and demonstrate that this interaction is within specific axonal compartments.